Chapter Eleven
Other Health Conditions
ASD people are like a canary in the coal mine, in that they often have increased sensitivity to the various factors negatively affecting everyone to some degree.
If too much inflammation occurs in the womb or early in life, then that can cause ASD. However, if the challenge occurs later in life, then that can lead to many different conditions, such as anxiety, depression, bipolar, cancer, Alzheimer’s, or Parkinson’s. Of course, there are many more health conditions where chronic inflammation is the main cause. Inflammation affects different areas of the body in different people, depending on many factors such as lifestyle choices and epigenetics.
As discussed, inflammation can cause the body to change regular functions. These changes often have a temporary benefit that is not easily noticed. Many of these changes seem purposefully created to temporarily limit something worse from happening sooner.
In human history, the body’s purposeful and temporary modification of regular functions may have appeared and disappeared as excess inflammation also came and went. However, in modern society, there are multiple factors that create continually increased inflammation, such as pollution, incorrect nutrition, and psychological stress. In this modern scenario, temporary modification of regular functions can become destructive because inflammation does not allow those purposeful changes to turn back off.
In general, a better understanding and appreciation for the purposeful actions of the body will lead to better care. This is because this perspective provides a clearer picture of the factors involved in many different health conditions. Seeing the body with a fresh perspective will lead to medical care that is both preventative and naturally treats the factors causing different health conditions.
However, medicine must first overcome the limitations imposed by the current overspecialization and pill-based symptom management systems. The key to stopping this overspecialization is to fully recognize the importance of inflammation, which is like a highway that connects the separate overspecialized towns. Inflammation affects the entire body.
For this reason, this chapter focuses on some of the other health conditions that inflammation affects. Since this book is written to mainly discuss both the causes and treatments for ASD, this chapter is simply an overview of some of the other health conditions.
Alzheimer's and Parkinson's
One of the most significant challenges in the world is discovering the cause of Alzheimer’s disease. The primary symptom of Alzheimer’s is a progressive mental decline that causes memory loss. People forget their own families and even lose the sense of self. Alzheimer’s disease, which mostly affects the elderly, is projected to increase in the future because the population continues to get older.
Importantly, chronic inflammation impacts Alzheimer’s disease (AD). Various research “studies have established that immune system-mediated actions in fact contribute to and drive AD pathogenesis (792).” In addition, there are multiple reports non-steroidal anti-inflammatory drugs (NSAIDs) may have some preventative effects on this disease (793) (794) (795). Inflammation associates with increased microglia response, as discussed in Chapter 8. Given this information, it is no surprise research found “increased proliferation of microglial cells in human Alzheimer’s disease (796).”
As previously discussed, inefficient mitochondria produce more reactive oxygen species, which creates resistance to insulin and higher blood glucose levels. This increase in blood glucose happens because cells do not want to raise glucose metabolism when mitochondria are already struggling with damage caused by too many reactive oxygen species. This pattern of effects, when severe, causes type II diabetes.
Amazingly, research found that brain insulin resistance and “its consequences can readily account for most of the structural and functional abnormalities in AD (797).” Also, other researchers note that “glucose abnormality plays a critical role in AD pathophysiological alterations through the induction of multiple pathogenic factors such as oxidative stress, mitochondrial dysfunction, and so forth (798).”
As discussed in Chapter 6, excessive glucose metabolism damages the mitochondria. Too much glucose in the blood also increases inflammation. Therefore, eating too many refined carbohydrates can create excessive inflammation that damages the brain. Over a long time, this damage accumulates to the point that brain damage is much more noticeable.
Given this information, it is unsurprising research found “a dietary pattern with relatively high caloric intake from carbohydrates and low caloric intake from fat and proteins may increase the risk” of mild cognitive impairment or dementia in the elderly (799). Furthermore, Alzheimer’s involves such major glucose-related problems that some researchers think of Alzheimer’s as type 3 diabetes (800). In line with this idea, type 2 diabetes is “a significant risk factor for developing Alzheimer’s disease later in life (801).”
If high glucose intake increases the risk of brain damage, then limiting refined carbohydrate intake may improve brain health. Research found a ketogenic diet, which is low in carbohydrates, improved the Alzheimer’s Disease Assessment Scale-cognitive subscale score (802).
However, as mentioned, the ketogenic diet often does not have many important phytochemicals. Also, unless this diet is well-planned, the ketogenic diet does not provide enough micronutrients needed for long-term health.
A different type of diet that has more phytochemicals and micronutrients is the Mediterranean-Dash Intervention for Neurodegenerative Delay diet, known as the MIND diet. A study found an association between this diet and a significantly lower risk of Alzheimer’s disease (803). The phytochemicals and antioxidants in many of the foods in the MIND diet may reduce the inflammation and damage from glucose that is the primary cause of this disease.
A risk factor for Alzheimer’s disease is having the apoe4 lipoprotein. There are variations of this lipoprotein. Most people have apoe3. Fewer people have apoe4 lipoprotein, and even fewer have apoe2. Apoe4 is important because this lipoprotein version increases insulin resistance. In contrast, apoe3 does not cause as much resistance.
Interestingly, the apoe4 variation has a south-to-north gradient in Europe, “with the proportion of e4 carriers from only 10-15% in the south to 40-50% in the north (804).” In addition, apoe4 is more common in foraging communities, while more apoe3 variation exists in areas that have an agricultural economy (805).
Historically, both foragers and people in more northern climates had less consistent access to foods with a lot of carbohydrates. The apoe4 variation is an adaption that allows the eventual transformation of more glucose into fat for storage on the body. This increased storage as fat allowed people with limited glucose access to eat more carbohydrates when these foods were suddenly available. For example, during the fruiting of trees, apoe4 carriers could eat and store more of the fruit energy than apoe3 carriers. Evolutionarily, the apoe4 variation helped those people survive during limited food supply.
However, now high glucose foods are constantly available in modern society. Because of this, the ancient advantage of apoe4 is now a disadvantage. As mentioned, there is an association between more fat in the blood and insulin resistance, which is a reason authorities promoted a diet low in fat.
However, the actual problem is the combination of high fat with high glycemic load foods. This combination is an issue because glucose and fat are in competition to be metabolized by the mitochondria. A diet high in fat is not a problem if avoiding high glycemic load foods. In contrast, eating a lot of saturated fat with high glycemic load foods increases the amount of glucose in the bloodstream. This causes many health problems.
Apoe4 increases insulin resistance by causing more fat to remain in the blood, which limits the normal function of insulin. Although the metabolism of glucose creates more reactive oxygen species than fat metabolism, a frequently high blood glucose level also causes a lot of inflammation and damaging health effects. One of these health effects is glial cells releasing various inflammatory molecules. The glucose damage and higher inflammation combine to destroy many neurons. This is the reason apoe4 affects Alzheimer’s disease risk.
As a side note, the design of the brain is to metabolize glucose, ketones, and lactate because most fatty acids are unable to cross the blood-brain-barrier. However, the rest of the body is not designed to mainly metabolize glucose. Excess glucose metabolism throughout the body creates excess reactive oxygen species and diminishes antioxidant defenses. This impairs the brain’s ability to manage its own reactive oxygen species, creating damaged mitochondria.
As previously discussed, damaged mitochondria increase insulin resistance. Because of this insulin resistance, too much glucose accumulates in the brain’s blood. Over the long-term this causes too much inflammation in the brain and the destruction of many neurons.
If the issue in Alzheimer’s disease is too much glucose, then cancer, which rapidly removes glucose from blood, might reduce the risk of Alzheimer’s disease. Amazingly, researchers found the risk of developing dementia of the Alzheimer type is less among people that have a history of cancer (806). Glucose and its effect on inflammation is the main connection between these two health conditions.
For the previously mentioned reasons, stopping refined carbohydrate consumption and improving mitochondria function using the many ideas in this book may benefit Alzheimer’s and decrease the risk of getting the disease. Also, consuming a lot of fresh vegetables and fruits with their many phytochemicals is helpful. In addition, make sure to regularly fulfill all nutrient requirements.
Improvements may also happen by participating in many cognitively simulating activities. Research found “frequent participation in cognitively stimulating activities is associated with reduced risk” of Alzheimer’s disease (807).
Interestingly, other research using a mouse model found a 40 Hertz light flickering regime reduced amyloid-beta and affected genes associated with the transformation of microglia (808). However, the best way to drastically reduce the risk of Alzheimer’s disease may be to use the many different ideas in this book that reduce inflammation and improve overall quality of life.
Another neurodegenerative disorder that impacts some people is Parkinson’s disease. The primary symptom of this disease is progressively deteriorating muscle control. This loss of muscle control can eventually become fatal. Parkinson’s disease exerts its main effect in the brain by destroying dopamine-producing neurons. This depletes dopamine, a neurotransmitter required for proper muscle control.
Like Alzheimer’s, inflammation also affects Parkinson’s disease. Researchers found significantly higher oxidative stress markers in both diseases compared to controls (809). A study on Parkinson’s disease found increased levels of inflammatory cytokines and decreased levels of BDNF (810).
Inflammation is likely the link between alpha-synuclein accumulation and Parkinson’s disease. Research found alpha-synuclein inhibited complex I in electron transport chains and increased cell death (811). Inhibiting complex I increases the NADH/NAD+ ratio, which builds up energy potential at complex I. This increases the generation of superoxide, which can create hydroxyl, a very damaging reactive oxygen species. Perhaps the body uses the alpha-synuclein to help destroy damaged mitochondria.
Amazingly, research found dopamine-producing neurons are more vulnerable to oxidative stress (812) (813). Likely, this vulnerability is a purposefully designed warning system. The gradual loss of muscle control and slowly worsening symptoms is a warning system that something is wrong. Although Parkinson’s was rare in the ancient world, our ancestors understood something as significant as the loss of muscle control meant lifestyle changes needed to occur.
Also, since the loss of muscle control affects hunting and gathering, then it may have led to the benefits of fasting or eating less food. As discussed, fasting helps to destroy damaged cells and creates new efficient mitochondria. This reduces inflammation and may slow or reverse the effects of Parkinson’s disease. Therefore, there may be an evolutionary advantage for dopamine-producing neurons to be more sensitive to inflammation.
Another potential advantage of these neurons being more vulnerable to destruction is lowering dopamine increases insulin resistance. Research on mice found systemic dopamine depletion reduced peripheral insulin sensitivity, whereas activation of dopamine D1 receptor-expressing neurons increased insulin sensitivity (814). The researchers also used deep brain stimulation on humans to increase dopamine and noticed insulin sensitivity increased (814).
As discussed, when cells have too many reactive oxygen species, cells purposefully limit the ability for glucose to enter. The cells do so to limit the damage created when there is too much glucose metabolism. Because dopamine increases sensitivity to insulin, then destroying some of the dopamine-producing neurons reinforces the desire of other cells in the body to limit glucose metabolism when there is already too much inflammation.
Unsurprisingly, research found an association between type 2 diabetes and an 80 percent increased risk of Parkinson’s disease (815). Other researchers also found diabetes associated with a higher Parkinson’s disease risk (816) (817).
If the body is dealing with excessive inflammation, then the early destruction of dopamine neurons may help the inflammation not become worse. However, this probably served a more useful purpose in our evolutionary history when glucose supplies were not as abundant as they are now.
In modern society, high blood glucose levels combined with various lifestyle factors will increase inflammation, which may eventually cause the destruction of dopamine neurons and Parkinson’s disease. Also, in modern society, the greater insulin resistance associated with dopamine loss often worsens inflammation because most people eat refined carbohydrates that spike blood glucose levels.
In contrast, in ancient times, food did not increase blood glucose as much. Therefore, dopamine loss only slightly increased glucose levels in the bloodstream and helped to prevent more inflammation from occurring because of too much glucose metabolism.
Since Parkinson’s disease has such a strong link to inflammation, then using the ideas in this book may reduce Parkinson’s disease risk.
Depression, Anxiety, Bipolar
Inflammation is also the primary cause of many different mental health conditions, such as depression, anxiety, and bipolar. Importantly, researchers found “the odds of depression are higher in almost all inflammatory than in non-inflammatory illnesses (818).” Other researchers also remark how inflammation correlates with depression (819). Interestingly, the administration of inflammatory cytokines to “non-depressed individuals causes symptoms of depression (557).” Also, research about the depression risk in women found an “inflammatory diet pattern is associated with a higher depression risk (820).”
As discussed in Chapter 8, inflammation and the CDR increase excitation and reduce the number of connections between neurons. As a result, the brain reduces serotonin levels on purpose since serotonin is inhibitory and limits the excitation. Unfortunately, chronic inflammation can reduce serotonin so much that daily function and mood are negatively affected.
Selective serotonin reuptake inhibitors (SSRIs) are drugs designed to target serotonin to try to reduce depression symptoms. As the name implies, SSRIs partially block the natural and purposeful reuptake of serotonin into the cells, thereby keeping serotonin available in the synaptic space between the neurons for a longer time. This tricks the body into activating more serotonin receptors than it normally activates during inflammatory conditions. This sometimes reduces the symptoms of depression, but with negative side effects.
SSRIs also have anti-inflammatory effects (821). The anti-inflammatory effects of these drugs are likely a big part of why SSRIs have some beneficial effects on depression. Since inflammation lowers serotonin levels, then limiting inflammation will, in the long-term, lead to better results than taking SSRIs, which have negative side effects. If inflammation causes depression, then this condition may improve by using the ideas in this book.
Inflammation also influences the development of bipolar disorder (822) (823). Bipolar twins were found to have higher concentrations of thiobarbituric acid reactive substances (TBARS), which associates with reactive oxygen species damage (824). The same researchers also found more DNA damage and lower catalase activity in bipolar twins than in controls (824). Also, others report an association between bipolar disorder and higher levels of C-reactive protein, an inflammatory marker (825). People with bipolar may also have an increased frequency of autoimmune diseases and “inflammatory changes in the central nervous system (826).”
The balance of monoamine neurotransmitters, dopamine, serotonin, and norepinephrine affects bipolar disorder. Inflammation may diminish the number of monoamine neurotransmitters through limiting tetrahydrobiopterin (BH4), a cofactor for enzymes that create serotonin and dopamine (827). BH4 is also a cofactor for the biosynthesis of melatonin, norepinephrine, and epinephrine.
Importantly, multiple drugs used for bipolar treatment also reduce oxidative stress (828). Therefore, considering all this information, reducing inflammation using multiple nutrition and lifestyle modifications may improve bipolar disorder.
Also, as with most health conditions, make sure to track food intake to fulfill all micronutrient requirements. This is important because missing a single micronutrient can have significant health consequences and worsen various symptoms.
Another health condition inflammation strongly affects is anxiety. For example, research found an elevation of C-reactive protein, a marker of inflammation, in men with anxiety (829). Other research found the association C-reactive protein and Generalized Anxiety Disorder “was consistent with a linear dose-dependent relationship (830).” This means the higher the individual’s C-reactive protein level, then the more likely they had Generalized Anxiety Disorder.
Generalized Anxiety Disorder was also associated with more pro-inflammatory cytokines in comparison to anti-inflammatory cytokines (831). In addition, a study found an association between the production of some inflammatory cytokines and the severity of anxiety symptoms (832). More severe anxiety, such as panic disorder and posttraumatic stress disorder (PTSD), also has strong associations to increased pro-inflammatory cytokines. Research found that “87% of anxiety patients had six or more detectable levels of proinflammatory cytokines (833).” Inflammatory cytokines are also linked with endotoxin-induced anxiety, depressed mood, and lower performance of memory (834).
Amazingly, some supplements that reduce inflammation may also help anxiety. For example, dietary antioxidants reduced both anxiety and depression symptoms (835). Also, omega-3 fats, previously mentioned in Chapter 7, have anti-inflammatory effects, and might decrease anxiety. A study comparing omega-3 supplementation with placebo found people receiving an omega-3 supplement showed a “14% decrease in lipopolysaccharide (LPS) stimulated interleukin (IL-6) production and a 20% reduction in anxiety symptoms (836).”
Inflammation also affects mental health conditions by slowing down methylation. There is discussion of inflammation’s effect on methylation in Chapter 3. Methylation is important for mental health because methylation affects formation of monoamine neurotransmitters, such as dopamine and serotonin (837). These neurotransmitters strongly influence mental functioning and mood. Therefore, a dysfunctional methylation cycle creates imbalanced neurotransmitter levels. This can affect mental health conditions, such as anxiety, depression, and bipolar.
If inflammation affects these conditions, then using the ideas in this book may greatly reduce the symptoms and improve overall life quality. Of course, carefully tracking food intake and meeting all nutrient requirements is also important for healing these conditions.
Epilepsy
Epilepsy is a health condition that involves frequent seizures. People can have a mix of seizures, with some being noticeable and other seizures much harder to see. Some seizures may also be intense and overwhelming.
Interestingly, there may be a direct relationship between epilepsy and some features of autism (838). Seizures appear to affect many ASD people (839). Researchers found that the prevalence of epilepsy in ASD people was 38.3%, while the rate of epilepsy was only 1% in the non-ASD group (840). The study also found most epilepsy started to occur after the affected individual was twelve years of age (840).
This increased rate of epilepsy around the time of puberty is probably related to dopamine. This neurotransmitter reaches a peak during adolescence and is one reason for the risk-taking behavior found in many teenagers (841).
In agreement with this idea, there is an association between dopamine and multiple types of epilepsy (842). Research found injecting dopamine receptor D1 agonists started epilepsy in rats treated with a low dose of pilocarpine (843). In contrast, an injection of D1 antagonists prevented seizures induced by a high dose of pilocarpine (843). These studies support the idea of dopamine affecting epilepsy.
Although dopamine influences epilepsy, inflammation is probably the main cause of the condition. There happens to be “an increasing body of clinical and experimental evidence” supporting “the hypothesis that inflammatory processes with the brain might constitute a common and crucial mechanism in the pathophysiology of seizures and epilepsy (844).” Also, “genetic susceptibility to inflammation correlated with an increased risk of epilepsy (845).” While, administration of lipopolysaccharide (LPS), which raises inflammation, also increases seizures (846).
Inflammation affects epilepsy by increasing glutamate, the excitatory neurotransmitter discussed in Chapter 8. Excessive excitation created by too much glutamate explains many epilepsy symptoms. Also, a study found an increase in extracellular glutamate stimulates epilepsy, and glutamate blockers may be powerful anticonvulsants (847).
Since inflammation is likely the main cause of epilepsy, then using the ideas in this book may significantly reduce seizures. Of course, as with other health conditions, using an approach covering multiple angles is critical. Sleep, light, nutrition, exercise, and stress are all important.
This chapter is only a summary of just a few of the many health conditions inflammation causes. Naturally reducing inflammation improves a massive variety of health conditions. In contrast, using medications for long-term symptom management may cause negative side effects, lower life quality, and increase the risk of an early death.
Unfortunately, because of overspecialization and overuse of advanced technology for zooming closer in, many are not able to see the bigger picture where simple, powerful healing solutions are found. Excess inflammation is the main cause of most seemingly complex health conditions.
If you, or someone you know, struggle with health, then comprehensively using the many ideas in this book may reduce inflammation and improve overall health.